Fig. 5. In situ hybridization studies of terminal oligodendrocyte differentiation in early postnatal spinal cords of mice carrying Sox8- and Sox10-null alleles. In situ hybridization with probes specific for Mbp (A-D,I-L) and Plp (E-H,M-P) were performed on transverse spinal cord sections from the forelimb region at postnatal day 3 (A-H) and postnatal day 7 (I-P). (A,E,I,M) Wild-type spinal cords; (B,F,J,N), Sox8^lacZ/lacZ spinal cords; (C,G,K,O), Sox10^+/lacZ spinal cords; (D,H,L,P), Sox8^lacZ/lacZ, Sox10^+/lacZ spinal cords.