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Fig. 5. Vertebral defects in Dkk1 mutants. (A-C) Kinked tail in adult mice. (D) Vertebral fusions in the tail of Dkk1d/– compound heterozygote, E18.5. (E-G) Vertebral fusions in sacral and lumbar regions of E18.5 embryos; arrow, hemivertebra. Dkk1 genotypes are indicated.