Fig. 7. Rescue of axial truncation in Lrp6 null mice by reduced expression
of Dkk1. Genotypes are indicated with Dkk1 above and
Lrp6 below. (A-C) E16.5 embryos demonstrating axial truncation; (D)
small size of Dkk1d/dLrp6–/– double
mutant at P1; (E) fusion of lumbar and sacral vertebrae, compare with
wild-type control in Fig. 5E;
(F) Correction of posterior digits in E16.5 forelimbs. (G) Cross-section of
forelimb at E17.5 stained with hematoxylin and eosin. Arrow, ectopic ventral
tendon (v). (H) Normal dorsal tendons in Dkk1d/d
homozygote.