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Fig. 1. Comparison of C. elegans WRN-1 with human Werner syndrome protein. WRN-1 shares 43% identity in amino acid sequence in the helicase motif and 25% identity in the RQC-HRDC region with human WRN. RQC, RecQ conserved domain; HRDC, helicase RNase D C-terminal conserved domain; NLS, nuclear localization signal.