Development -- Richard-Parpaillon et al. 131 (11): 2577 Figure IG2

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Fig. 2. Cyclin E but not cyclin A2 overexpression leads to apoptosis in the gastrula embryo. RNAs encoding cyclin E alone (a,A) or cyclin E with cdk2 (d,D,G), cyclin A2 alone (b,B) or cyclin A2 with cdk2 (e,E), cdk2 alone (f,F), Bgal as a control (c,C) or cyclin E with cdk2 and Bcl_XL (H) were injected into one cell of a 2-cell embryo and allowed to develop to stage 9 (a-f) or stage 11 (A-H). Areas of slowed cell division are indicated by black arrows (a,d,H). Areas of apoptosis are indicated by white arrows (A,D,G).