Fig. 2. Luciferase expression detected in the diaphragm and liver after hepatic in utero delivery of rAAV2-CBA-Luc. At 15 days gestation, Gaa^-/- fetuses were injected in the liver with 3x10⁷ infectious particles of rAAV2-CBA-Luc. Animals were sacrificed at 1 month and assayed for luciferase expression. The highest levels of luciferase activity were detected in diaphragm (A) and liver (B). Black circles reflect values of individual samples; white and gray bars represent averages from saline-treated and rAAV2-treated samples, respectively. Diaphragm expression is plotted on a log scale.