(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 3. Epidermal hole closure as part of natural morphogenetic episodes. Drosophila dorsal closure and C. elegans ventral enclosure. (A-D) Confocal micrographs of the dorsal surface of successively older Drosophila embryos expressing {alpha}-catenin-GFP that depict the four phases of dorsal closure: (A) initiation; (B) epithelial sweeping; (C) zippering; and (D) termination. LE, leading edge epidermis; AS, amnioserosa; VE, ventral ectoderm. (E-H) Scanning electron micrographs of the ventral surface of successively older C. elegans embryos similarly depicting dorsal intercalation and the three phases of ventral enclosure: (E) dorsal intercalation; (F) leading cell migration; (G) leading cell junction formation and fusion; and (H) ventral pocket enclosure. Leading edge cells (LE) are marked with an asterisk. LSH, lateral seam hypodermis; VH, ventral hypodermis. Anterior is towards the left in all images. (A-D) Courtesy of Sarah Woolner; (E-H) courtesy of Jim Priess.