Fig. 1. Defects in pancreas maturation in orpk mice. Pancreatic mass is reduced in orpk mice (B) when compared with wild type (A) at P9. To adjust for differences in body mass, pancreas weight was divided by body weight (C; blue, wild type, n=5; red, orpk, n=5). Progressive acinar cell loss and ductular hyperplasia increase in orpk mice with age (D,F-H) when compared with wild type (E,I). Gomori trichrome staining reveals a significant increase in collagen deposition in orpk pancreas (K) when compared with wild-type tissue (J). d, duodenum; dp, dorsal pancreas; s, stomach; vp, ventral pancreas.