Fig. 6. Pancreatic abnormalities in inversin and Pkd2 mice. Hematoxylin/Eosin staining of wild-type (A,C), inversin (B) and Pkd2 mice (D), showing changes in pancreas architecture. Staining for amylase and mucin indicates normal architecture in wild-type littermates (E,G), but acinar cell loss and ductal dilation in inversin and Pkd2 mice (F,H). Arrowheads in H indicate dilated ducts. Elevated levels of acinar cell apoptosis were observed in inversin mice (J) compared with wild-type littermates (I). No differences in apoptosis levels were detected between Pkd2 (L) and wild-type (K) E14.5 embryos.