Fig. 7. Abnormal expression of ß-catenin and Lef/Tcf family members in orpk mice. In wild-type pancreatic sections ß-catenin is predominately localized to the cell membrane (A; arrows in higher magnification image, C). In orpk mice, cytoplasmic ß-catenin localization in dilated ducts (arrowheads) is increased (B; and at higher magnification in D). (E) Expression of Lef/Tcf family members in control littermates (first lane) and orpk mice (second and third lane). Actin was used as a control gene.