Fig. 6. Morphological alterations of the brain in Sox2^ß-geo/ENH mutants. (A) Dorsal view of wild-type (top) and mutant (bottom) brains. The shrinkage of the medial-posterior cortex is particularly visible in this mutant. (B-F) Coronal sections through adult forebrain of a normal (top) and a mutant (bottom) mouse. Sections were matched between normal and mutant brains on the basis of the correspondence of characteristic anatomical landmarks (hippocampus, thalamic nuclei and fibre tracts). Left, anteriormost; right, posteriormost. Asterisk indicates thalamic nuclei (see Fig. 2F). Black circle, dorsal striatum; white circle, septum; arrowhead and arrow in E, corpus callosum. Black arrow in F-H marks the diminished extension of the cortex. (G-I) Coronal sections at E14.5 (G,H) and P0 (I) of normal (top) and mutant (bottom) brains. Note, in G and H, the ventricles of the mutant are normal, and the thalamus and striatum sizes are essentially normal, in contrast to the reduced cortex (particularly visible in H).