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Fig. 8. Regulation of vent and vox by Wnt8 and zygotic BMP. (A) vent and vox are induced around MBT by an unknown factor. (B) At 40% epiboly, Wnt8 is required to maintain high levels of vent and mesodermal vox expression. (C) At 70% epiboly, in addition to Wnt8, zygotic BMP is required to maintain vent expression. BMP is also required for ectodermal vox expression. Thicker arrows represent stronger regulatory connections, as vent and ectodermal vox expression is absent in zygotic BMP mutants at this stage, whereas vent and mesodermal vox expression are only reduced in wnt8 mutants.