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Fig. 7. Disp1 genetically interacts with Ihh signaling at the early stage of embryonic development from E7.5 to 9.5. External morphology of E9.5 dpc embryos: (A) wild type; (B) Shh–/–; (C) Disp1{Delta}2/C829F, Shh–/–. Heart looping is clearly visible in wild-type (A) and Shh–/– (B) mutant. No heart looping occurs in Disp1{Delta}2/C829F, Shh–/– (C). Whole-mount in-situ of Dbx1 expression in wild type (D), Shh–/– (E) and Disp1{Delta}2/C829F, Shh–/– (F).