Fig. 6. Specific changes in gene expression in skin of Hr^-/-mice. (A) Northern analysis of total RNA extracted from backskin of P12 mice using the indicated probes. casp-14, caspase 14; calm-4, calmodulin 4/Scarf. ß-Tubulin shows equal RNA loading on a representative blot. (B) Developmental expression of K10, loricrin, filaggrin and caspase 14. Northern analysis of RNA prepared from the skin of mice at indicated ages with the designated probes. ß-Tubulin is shown as an RNA loading control. +/+, wild type; -/-, Hr^-/-.