Fig. 3. Rb ablation leads to cell lineage-specific effects in differentiation. (A-F) Immunohistochemical analysis for CCSP and CGRP in lungs from day 1 pups after Rb ablation (CC10-rtTA), from genetically identical pups without doxycycline treatment (No dox), and from pups lacking one or both transgenes (Control). Arrows mark neuroendocrine cells. Abbreviations are as in Fig. 1. Data represent analysis of seven CC10-rtTA, eight Control and four No Dox lungs.