Fig. 7. Rb family deficiency results in cell lineage-specific effects in differentiation. (A-F) Immunohistochemical analysis for CCSP and CGRP in transgenic and wild-type (WT) control lungs. Arrows mark neuroendocrine cells. Data is representative of three to six CC10-T121 founder mice and two SPC-T121 pups. (G) Immunohistochemistry for the transgene (T121) and CCSP in a CC10-T121 founder with a less severe phenotype. Note that transgene expression (green) and CCSP expression (red) do not overlap. Abbreviations are as in Fig. 1. (H) Quantification of CGRP-immunoreactive foci. CC10-T121 mice show increased CGRP-reactive foci when compared with wild-type (WT) (^*P=0.0002) and SPC-T121 (^*P=0.0008) mice. Data represent six CC10-T121 founder mice, four wild-type mice and two SPC-T121 mice.