Fig. 7. (A) Model for maintenance of the apical PCP protein complex (prior to PCP signaling, e.g. anterior to MF). Known physical interactions are highlighted in blue (this work) (Tree et al., 2002; Jenny et al., 2003). The predicted Fmi-mediated complex, containing also Fz, Stbm and Dsh, is stable when either Dgo or Pk are removed, but unstable in the double mutant. (B) Proposed model for PCP signaling circuitry during PCP signaling, e.g. in R3/R4 cells. Fmi is maintained through Dgo function in R3 and Stbm/Pk in R4. Known physical interactions are in blue (Jenny et al., 2003; Tree et al., 2002). Factors depicted in gray are downregulated through PCP signaling at this stage. See text for details.