Fig. 9. Model for glide pathway in tendon cell development. While Hh and
Wg signaling directly control stripe expression in border cells, they
act indirectly (dotted arrow) on glide. stripe b controls the
expression of several genes involved in early tendon cell differentiation
(left panel) as well as its own expression
(Vorbruggen and Jackle, 1997);
glide-glide2 have no influence on their expression (left panel).
glide, glide2, and stripe b, are able to induce
alien expression, indicating that the two pathways have common
targets. Whether this regulation is direct or indirect remains to be
determined (broken arrows). The glide complex directly activates its own
pathway (Ent2). glide participates in stripe b
regulation during late tendon cell differentiation. Finally, unknown
glide, glide2, stripe b, alien and Ent2 targets are also
indicated by a question mark.