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Fig. 8. CAR3-mediated cardiac expression requires the collaboration of multiple factors. Diagram outlines three arms of BMP signaling that synergistically activate CAR3-driven cardiac expression: SMAD nuclear localization and direct interaction with SBE sites located in CAR3; induction of cardiac GATA proteins; and SMAD-mediated modulation of the activity of the ubiquitously expressed YY1 repressor/activator.