Fig. 2. The effect of FrdMO and DprMO on neural plate closure. (A-C) CoMO (A), FrdMO (B) or DprMO (C) were injected into the right animal dorsal blastomere of 8- to 16-cell stage embryos without (left panels) or with (right panels) nuclear ß-galactosidase (nßgal) RNA, a lineage tracer. Doses of MOs and mRNAs are as indicated in Table 2. (B,C) Neural plate closure and neural fold formation is severely disturbed on the injected side as evidenced by RedGal staining. Arrowheads indicate the neural plate border. Scale bars: 150 µm.