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Fig. 6. The involvement of Frodo and Dapper in different steps of Wnt signal transduction. (A) Frodo and Dapper synergize with TCF3-VP16 to activate the pSiaLuc reporter in Xenopus embryos. (B) The amount of ß-catenin associated with GST-TCF3 is not altered by Frodo. (C) Frodo/Dapper are not required for ß-catenin-dependent reporter activation. (D) An inhibitory activity of Frodo and Dapper revealed in Wnt8-dependent stimulation of pSiaLuc.