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Fig. 5. Pcm heterozygous mutant spleens exhibit functional competence for red pulp hyperplasia and red blood cell clearance. (A) Spleen weights demonstrate a transient increase in Pcm heterozygotes at 7 weeks of age. *, P<0.01. Phenylhydrazine treatment of 3-week (B) and 7-week-old mice (C) demonstrates reduced splenic hyperplasia in Pcm heterozygotes. **, P<0.0001. (D) Prussian blue staining of P0 spleen reveals no iron accumulation in wild-type or Pcm heterozygous mutants. Original magnification, 200x. (E) At 12 weeks of age, Pcm heterozygotes display significant red pulp iron accumulation. Original magnification, 100x.