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Fig. 1. Mutations in paralogous Hox genes cause dramatic disruptions of limb skeletal morphology. (A-D) Alcian Blue/Alizarin Red-stained limbs. Forelimbs of (A) control newborn and (B) Hoxa11/Hoxd11 double mutants; hindlimbs of (C) control and (D) Hoxa10/Hoxc10/Hoxd10 triple mutant newborn.