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Fig. 4. Forelimb development is delayed in Hoxa11/Hoxd11 double mutant embryos. (A) Limb bud of E11.5 control embryo [stage 6 limb bud (Wanek et al., 1989)]. (B) Limb bud of E11.5 Hoxa11/Hoxd11 double mutant embryo (stage 5-6). (C) Stage 8 limb bud of E12.5 control embryo. (D) Limb bud of double mutant E12.5 embryo of approximately the same crown-rump length as control embryo shown in C. Limb bud appears to be at stage 6-7. (E) Stage 9 limb bud of E13.5 control embryo. (F) Limb bud of Hoxa11/Hoxd11 mutant embryo of approximately the same size as control embryo in E. Limb bud appears to be at stage 8-9, and indentations between digits are slightly deeper in control embryo (arrows in E,F).