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Fig. 5. Fgf8 and Fgf10 expression patterns in double mutant embryos. (A) Fgf8 expression in stage 3 limb bud of control embryo and (B) Hoxa11/Hoxd11 double mutant embryo. Fgf8 stained region is narrower in double mutant forelimb bud. (C) Fgf8 staining in control embryo with stage 4-5 forelimb buds. (D) Stage 4-5 double mutant forelimb bud hybridized with Fgf8 probe. Staining with Fgf8 probe is weaker in anterior AER of mutant embryo than in control (arrows). (E) Expression pattern of Fgf10 in E11.5 control embryo and (F) E11.5 double mutant. Arrows indicate the alteration in the staining pattern in the anterior limb bud mesenchyme.