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Fig. 2. Structural analysis of Dd-STATb. (A) The C{alpha} trace of Dd-STATb (blue), superimposed on STAT1 (magenta), was used as a template for modelling Dd-STATb. The invariant arginine at position ßB5 is shown in red (in STAT1) and its equivalent residue in Dd-STATb, a leucine, is shown in blue. The two main inserts are highlighted. (B) Dd-STATb is superimposed on the Src SH2 domain, with the arginine/leucine variation highlighted and the Src phosphopeptide also shown. (C) A ribbon diagram of Dd-STATb (in blue) superimposed on the whole structure of STAT1, showing that the position of the large insert (insert1) would not disrupt a similar dimerisation as that seen for STAT1. (D) The C{alpha} trace for Dd-STATb (red), STAT1 (blue) and STAT3 (green). The phosphorylated Serine residues are shown in STAT1 and STAT3. It is apparent that the positions of insert 1 and insert 2 are regions of dissimilarity in both STAT1 and STAT3.