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Fig. 3. Histological examination of epididymis and testis. (A-C) Transverse section through the epididymis. Spermatazoa are infrequent in Arflox(ex1-neo)/Y and absent from Arflox(ex1-neo)/Y; Amh-cre males. Pyknotic and vacuolated round spermatids populate the Arflox(ex1-neo)/Y; Amh-cre epididymis. Smooth muscle hyperplasia is apparent in Ar mutants. (D-F) Low magnification view of testis transverse section. Elongated spermatids are depleted from Arflox(ex1-neo)/Y; Amh-cre testes. (G-I) Stage VII tubules show decrease in (Arflox(ex1-neo)/Y) or complete absence of (Arflox(ex1-neo)/Y; Amh-cre) elongated spermatids. (J-L) Higher magnification of G-I. Black arrowhead indicates presence of degenerating sperm in Arflox(ex1-neo)/Y males.