Fig. 2. Altered levels of cell death in Smo^c/–;Foxg1^Cre mutants. (A-D) E10.5 coronal sections of the telencephalon stained with antibodies against BrdU (A,B) or caspase and TuJ1 (C,D). Smo^c/–;Foxg1^Cre mutants have a general increase in cell death at E10.5 and an absence of the earliest differentiating neurons (D) as compared with wild-type littermates (C). (E,F) E12.5 coronal sections of the telencephalon stained with antibodies against caspase and TuJ1. Smo^c/–;Foxg1^Cre mutants show continued widespread cell death with the exception of the dorsal cortical midline (F). Note that the pattern of TuJ1 expression in mutant embryos (F) resembles that seen in wild-type LGE (E). Scale bars: 200 µm in A-D; 300 µm in E,F.