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Fig. 5. Chamber differentiation in the myocardium of the AVC in Tbx2tm1Pa/Tbx2tm1Pa mutants (–/–), 9.5 dpc. Various gene expression patterns in normal wild-type (+/+) or heterozygous (+/–) embryos (A,C,E,G,I,K,M,O,Q,S,U,W) compared with homozygous mutants (B,D,F,H,J,L,N,P,R,T,V,X). Nppa is ectopically expressed in myocardium at the atrioventricular canal (AVC) in homozygous mutants (B), as is Csl (D) and Cx40 (F). Some homozygous mutant embryos have an extended domain of Cited1 expression into the AVC (H). Tbx5 expression at the AVC is normal in homozygous mutants (J). MLC2v expression is normal (L), but abnormal atrial expression of ßMHC (N) is observed in homozygous mutants. eHAND expression is normal in homozygous mutants (P). Neural crest cell Crabp1 expression is normal in homozygous mutants (R). Expression of Islet1 and the Fgf10 enhancer-trap transgene 1v-nlacZ-24 are normal in 9.5 dpc homozygous mutants (T,V). 1v-lacZ-24 expression is also normal in homozygous mutants at 12.5 dpc.