Fig. 7. The misregulation of Xnr3 and Xnr5 in FoxH1-depleted embryos contributes to the later abnormalities. (A) Control and FoxH1-depleted embryos injected with 150 pg Xnr3 mRNA in one dorsal animal cell at the eight-cell stage. Xnr3 overexpression causes convergence extension defects in control embryos and partially rescues head formation in FoxH1-depleted embryos. (B) The relative expression levels of Xnr5 and Xbra mRNA in wild-type early gastrulae injected with 0, 600, 60, 6 and 0.6 pg of Xnr5 mRNA into one ventral cell at the four-cell stage. (C) The phenotype of sibling embryos of those frozen in (B).