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Fig. 8. Strong synergy between TrkN-LRP6C and NT3-HFz5 in Wnt/ß-catenin signaling. (A) Schematic representation of human FZ5, LRP6 and the NT3-HFz5 chimera. NT3 was fused to the N terminus of human FZ5 to form NT3-HFz5. (B) Synergetic effect of TrkN-LRP6C and NT3-HFz5 on LEF-dependent transcription. S2 cells were transfected with the indicated plasmids. Luciferase activities were measured 48 hours after transfection.