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Fig. 1. Progressive pigmentation in orJ retinas. (A-H) Eyes were sectioned to analyze for pigmentation in orJ/+ heterozygous (A,C,E) or orJ/orJ homozygous (B,D,F,G,H) littermates. Ages are indicated on the figure. (A,B) Insets show a full section of the eye (note scale bar differences). (B,D,F) Arrows indicate the central limit of ectopic pigmentation in the retinas of orJ mutants. (D) The lens is marked by a thin black line in the orJ eye at E17.5. (G,H) The peripheral retina in orJ mutants shows ectopic pigmentation, increasing over time until most of the retina appears pigmented at P15. (H) The presumptive retina is marked with arrowheads. Scale bar is 100 µm.