Fig. 2. TrkA deficiency does not affect spleen development and skin mast cells. Spleens of wild-type (A,C,E,G) and mutant (B,D,F,H) mice were stained with hematoxylin/eosin (A,B), Apoptag (C,D), and B cell- (anti-B220; E,F) and T cell-specific (anti-CD3; G,H) antibodies. Note the absence of any remarkable difference between mutant and control organs. (L,M) Toluidine-blue staining of mutant (M) skin samples shows presence of mast cells (arrows) in number and distribution similar to wild-type littermate controls (L). LF, lymphoid follicle.