Fig. 5. Absence of TrkA does not impair T-cell-dependent memory nor T-cell-independent type I and II B responses. (A) For the TD memory response, T1-Cre;TrkA^neo/neo (n=7) and control littermates (n=6) were immunized with KLH-TNP as described in Materials and methods. (B,C) for the TI type I and II responses, mice were immunized respectively with LPS-TNP (B, six mutants and five controls) or Ficoll-TNP (C, six mutants and seven controls). Serum levels of specific anti-TNP Igs were measured by ELISA before immunization (0), at one (1) and two (2) weeks after the challenge. Bars: means±s.e.m. Data were evaluated using a two-tailed Student's t-test. ^*P<0.05.