Fig. 6. Sensory nerve defects in Y1227F knock-in mutants. Homozygous E12.5 knock-in embryos were subjected to whole-mount immunostaining using anti-neurofilament antibodies. The morphologic appearance of the sensory cutaneous nerves in the thoracic cavity wall region is shown for (A) Erbb2^wt/wt (B) Erbb2^{Y1028F/Y1028F} (C) Erbb2^{Y1144F/Y1144F} and (D) Erbb2^{Y1227F/Y1227F}. Note that the nerves in D are disorganized and defasciculated.