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Fig. 4. Zebrafish intrahepatic biliary development occurs independently of liver vasculature. (A,B) Histological cross-sections through the liver of wild-type (A) and cloche mutant (B) 80-hpf embryos processed for cytokeratin IHC. Developing bile ducts (arrows) are present in both wild-type and cloche embryos. e, esophagus; l, liver; ph, pharynx; p, pronephric duct. Asterisk indicates sinusoids.