Development -- Brugmann et al. 131 (23): 5871 Figure IG6

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Fig. 6. (A) Control zic2 expression; bracket indicates LNE domain. (B) Overexpression of six1-WT expands the zic2 LNE domain (bracket). (C) Six1 knock-down expands the zic2 LNE domain (bracket). (D) Control dlx6 expression. (E) Overexpression of six1-WT moves the dlx6 stripe laterally (arrow), and in some cases eliminates expression in places (arrowheads, inset). (F) Six1 knockdown reduces the lateral dlx6 stripe (arrow). (G) Overexpression of sox2 reduces six1 (arrow). (H,I) Overexpression of foxD3 (H) reduces six1 (arrow) and (I) expands zic2 LNE expression (arrow). (J,K) Over-expression of zic2 (J) reduces six1 (arrow) and (K) expands foxD3 (arrow). (L) Over-expression of dlx5 reduces six1 (arrow). mRNAs were injected on left-hand side; right-hand side is internal control.