Development -- Stickens et al. 131 (23): 5883 Figure IG5

(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.

Fig. 5. Phenotype of MMP13fl/fl;Col2-Cre^+/– endochondral bones. (A,B) Safranin-O stained metatarsals from 2-week-old wild-type and MMP13fl/fl;Col2-Cre^+/– mice show an increased hypertrophic chondrocyte (HC) zone in MMP13fl/fl;Col2-Cre^+/– mice similar to that observed in Mmp13^–/– mice (compare with Fig. 1D,E). (C,D) Picrosirius red-stained femurs from 10-week-old wild-type and MMP13fl/fl;Col2-Cre^+/–. MMP13fl/fl;Col2-Cre^+/– mice lack the increased trabecular bone (TB) phenotype observed in the Mmp13^–/– mice, but have an altered structure of the trabeculae (arrow). SO, secondary site of ossification. Scale bars: 100 µm in A,B; 300 µm in C,D.