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Fig. 1. Pancreatic Gdf11 expression detected by in-situ hybridization. (A) Expression of Gdf11 (purple) in dorsal pancreas epithelium at E11.5. Little-to-no expression of Gdf11 mRNA is detected in pancreatic mesenchymal cells that surround the epithelium. (B) Expression of Gdf11 (purple) in dorsal pancreas, ventral pancreas and stomach epithelium, duodenal epithelium and kidney (inset) at E13.5. (C) Expression of Gdf11 (purple) in exocrine acinar cells and duodenal epithelium at E18.5. Little-to-no Gdf11 expression was detected in islets. Blood cells are stained black in this panel. (D) Sense control at E18.5. Labels are the same as in C. d, duodenal epithelium; dp, dorsal pancreas epithelium; e, exocrine acinar cells; i, islets; k, kidney; s, stomach epithelium; vp, ventral pancreas epithelium.