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Fig. 5. Has2 and Rac1 act in a cell autonomous fashion, promoting lamellipodia formation. All panels show individual lateral mesodermal cells at the 80% epiboly stage, visualized with membrane-localized GFP. Dorsal is to the right, anterior to the top. (A) Wild type; (B) has2 morphant; (C) wild type injected with mRNA encoding dominant-negative Rac1 (dnRac1); (D) has2 morphant injected with mRNA encoding constitutively active Rac1 (caRac1); (E) wild-type cells transplanted into has2 morphant host; (F) has2 morphant cells transplanted into wild-type host; (G) wild-type cells transplanted into host expressing dnRac1; (H) dnRac1-expressing cells transplanted into wild-type host.