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Fig. 2. Abnormal cell divisions in sur-6(sv30) embryos. Cell division patterns (A-F), chromosome segregations during anaphase (G,H) and spindle orientation (I,J) were examined in wild-type embryos (A,C,E,G,I) or embryos produced by sur-6(sv30) mothers (B,D,F,H,J). (A-F) Nomarski images. (A) Wild-type embryo showing normal anaphase spindle in the AB cell. (B) sur-6(sv30) embryo showing an abnormal L-shaped spindle in the AB cell. (C) Wild-type embryo in which AB has divided before P1. (D) sur-6(sv30) embryo in which P1 has divided before AB. (E) Wild-type embryo showing the orthogonal orientation of the ABar and ABpr spindles. Doubleheaded arrows indicate the orientation of the spindle. (F) sur-6(sv30) embryo showing parallel orientation of the ABar and ABpr spindles. A similar defect has been reported in some Wnt pathway mutants (Rocheleau et al., 1997; Thorpe et al., 1997). (G,H) DAPI staining. (G) Wild-type one-cell embryo showing a normal anaphase figure. (H) sur-6(sv30) one cell embryo with anaphase bridging defects (arrow). (I,J) Anti-tubulin staining. (I) Wild-type multicellular embryo showing two centrosomes per dividing cell. (J) sur-6(sv30) multicellular embryo showing a dividing cell with supernumerary centrosomes (arrows).