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Fig. 3. Dorsal endoderm of Flk1-/- embryos expresses Foxa2 and Hnf6 and Shh expression is repressed, as in control embryos. In situ hybridization of control (A,C,E) and Flk1-/- (B,D,F) embryos with probes of Foxa2 (A,B), Hnf6 (C,D), and sonic hedgehog (E,F). nc, notochord. Somite stages are indicated in each panel.