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Fig. 2. Defective spermatogenesis in Mili-deficient mice. (A) Immunostaining of 14.5-dpc gonads with the anti-MVH antibody. Sections from heterozygous (+/-) and homozygous mutant (-/-) littermate embryos were stained with the anti-MVH antibody (I, II) or DAPI (III, IV). (B) Comparison of the testes from 10-week-old wild type (+/+), heterozygous (+/-) and homozygous mutant (-/-) mice. The testis from the Mili-/- mouse is smaller. (C) Weights of testes from wild-type (+/+), heterozygous (+/-) and homozygous mutant (-/-) mice. (D) Hematoxylin and Eosin-stained sections of testes from 10-week-old mice. Sections from the heterozygous (I, III) and homozygous mutant (II, IV) mouse testes are shown.