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Fig. 3. Morphometric analysis. Fractional airspace and fractional lung parenchyma were calculated in lungs of mice from each genotype after exposure to doxycycline for the defined times. Fractional airspace ratio was significantly increased in SP-C-rtTA but not CCSP-rtTA, Fox2{Delta}/{Delta} mice. *P<0.05 vs control mice (Student's t-test).