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Fig. 1. Expression of Pitx3 in wild-type (A,C,E) and ak mutants (B,D,F) in the adult brain (A-D) and at stage E12.5 of brain development (E,F). Pitx3 was not expressed in the brains of ak mice. SNc, substantia nigra compacta; VTA, ventral tegmental area; MF, mesencephalic flexure.