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Fig. 10. Graphical representation of the pattern of cell genesis and migration in the midbrain. (A) Reported models for development of the mesencephalic dopaminergic (mesDA) neuronal field combined with tyrosine hydroxylase (Th) staining in coronal sections of E12.5 midbrain. The neuroepithelium is marked by a double line. Model 1 represents vertical migration followed by lateral migration. Model 2 represents perpendicular migration of SN precursors and ventral migration of VTA precursors. The direction of the migration in both models is indicated by arrows. (B) Schematic drawing representing the molecular events of mesDA development, in line with model 2. Aq, aqueduct.