Fig. 7. Neuron numbers are unchanged in E12.5 K14-noggin trigeminal ganglia. (A) Total number of ß-tubulin positive neurons in the trigeminal ganglion is unchanged in K14-noggin compared with wild-type littermates. Mean and s.e.m. of four animals of each genotype are shown. (B) Total number of BrdU-positive cells is not significantly different in K14-noggin versus wild-type trigeminal ganglia. Means and s.e.m. of four animals of each genotype are shown. (C) Total number of TUNEL-positive cells is unchanged. Mean and s.e.m. of four animals of each genotype are shown. (D) Neuron numbers in the trigeminal ganglion decrease by about 33% between E12.5 and adult life in wild type but do not change in the K14-noggin animals (^*P<0.02).