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Fig. 2. Hoxb1 regulates early differentiation of noradrenergic visceral sensory interneurons in r4. (A-D) Hindbrain flat-mount preparations showing Dbh and Rnx expression are missing in dorsal r4 of E11.5 Hoxb1-/- embryos compared with control littermates. (E,F) Expression of Phox2b mRNA is significantly reduced in dorsal r4 of E10.5 (insets) and E11.5 Hoxb1-/- embryos compared with control littermates.