Fig. 5. PRO-1 is a member of a subfamily of WD-repeat proteins. Unbroken blue bars indicate WD-repeats in the underlying sequence (based on http://bmerc-www.bu.edu/wdrepeat/celegans/R166_CE_NEW.html); broken bars indicate possible degenerate repeats. The D211 residue is in red. Alignment from ClustalW (MacVector). Identical residues are boxed and shaded when present in more than four proteins; a consensus of these amino acids is given under the alignment. Sequences (NCBI locus names) are protozoan T. brucei (CAB95350), fission yeast S. pombe (NP_593710), budding yeast S. cerevisiae (NP_014217), plant A. thaliana (NP_190487), C. elegans (NP_496271), fly D. melanogaster (NP_569954) and H. sapiens (NP_077005). BLAST E-values against full-length PRO-1 range from 2.3x10^-36 (human) to 1.9x10^-10 (S. cerevisiase).