Fig. 8. A current working model for how Bmp signals maintain GSCs in the
Drosophila testis. In this model, Upd from hub cells, Gbb/Dpp from
hub cells/somatic stem cells are important for GSC maintenance. An unknown
signal initiated by EGFR/Raf signaling from somatic cyst cells is important
for the proper differentiation of gonialblasts. Dpp/Gbb signaling also helps
repress bam expression in GSCs and in gonialblasts (GBs). Two-cell
germ cell clusters distant from hub cells/somatic stem cells receive less Bmp
signaling and begin to express bam and promote further
differentiation.